Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model.
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ABSTRACT:
SUBMITTER: Perera DJ
PROVIDER: S-EPMC7701121 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Adjuvanted <i>Schistosoma mansoni</i>-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model.
Perera Dilhan J DJ Hassan Adam S AS Jia Yimei Y Ricciardi Alessandra A McCluskie Michael J MJ Weeratna Risini D RD Ndao Momar M
Frontiers in immunology 20201116
Schistosomiasis threatens 800 million people worldwide. Chronic pathology manifests as hepatosplenomegaly, and intestinal schistosomiasis caused by <i>Schistosoma mansoni</i> can lead to liver fibrosis, cirrhosis, and blood in the stool. To assist the only FDA-approved drug, praziquantel, in parasite elimination, the development of a vaccine would be of high value. <i>S. mansoni</i> Cathepsin B (SmCB) is a well-documented vaccine target for intestinal schistosomiasis. Herein, we test the increas ...[more]
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