Neuroplastin Modulates Anti-inflammatory Effects of MANF.
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ABSTRACT:
SUBMITTER: Yagi T
PROVIDER: S-EPMC7702011 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Neuroplastin Modulates Anti-inflammatory Effects of MANF.
Yagi Takuya T Asada Rie R Kanekura Kohsuke K Eesmaa Ave A Lindahl Maria M Saarma Mart M Urano Fumihiko F
iScience 20201117 12
Endoplasmic reticulum (ER) stress is known to induce pro-inflammatory response and ultimately leads to cell death. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER-localized protein whose expression and secretion is induced by ER stress and a crucial survival factor. However, the underlying mechanism of how MANF exerts its cytoprotective activity remains unclear due to the lack of knowledge of its receptor. Here we show that Neuroplastin (NPTN) is such a receptor for MANF. Bio ...[more]
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