Ontology highlight
ABSTRACT:
SUBMITTER: Deryugina E
PROVIDER: S-EPMC7702017 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Deryugina Elena E Carré Alexia A Ardi Veronica V Muramatsu Tomoki T Schmidt Jonas J Pham Christine C Quigley James P JP
iScience 20201113 12
Functional roles of neutrophil elastase (NE) have not been examined in distinct steps of the metastatic cascade. NE, delivered to primary tumors as a purified enzyme or within intact neutrophils or neutrophil granule content, enhanced human tumor cell intravasation and subsequent dissemination via NE-mediated formation of dilated intratumoral vasculature. These effects depended on picomole range of NE activity, sensitive to its natural inhibitor, α1PI. In <i>Elane</i>-negative mice, the lack of ...[more]