Ontology highlight
ABSTRACT:
SUBMITTER: Parrow A
PROVIDER: S-EPMC7704030 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Parrow Albin A Larsson Per P Augustijns Patrick P Bergström Christel A S CAS
Molecular pharmaceutics 20200904 10
Efficient delivery of oral drugs is dependent on their solubility in human intestinal fluid, a complex and dynamic fluid that contains colloidal structures composed of small molecules. These structures solubilize poorly water-soluble compounds, increasing their apparent solubility, and possibly their bioavailability. In this study, we conducted coarse-grained molecular dynamics simulations with data from duodenal fluid samples previously acquired from five healthy volunteers. In these simulation ...[more]