Dataset Information

Acute effect of ambient fine particulate matter on heart rate variability: an updated systematic review and meta-analysis of panel studies.

ABSTRACT:

Background

Decreased heart rate variability (HRV) is a predictor of autonomic system dysfunction, and is considered as a potential mechanism of increased risk of cardiovascular disease (CVD) induced by exposure to particulate matter less than 2.5 ?m in diameter (PM_2.5). Previous studies have suggested that exposure to PM_2.5 may lead to decreased HRV levels, but the results remain inconsistent.

Methods

An updated systematic review and meta-analysis of panel studies till November 1, 2019 was conducted to evaluate the acute effect of exposure to ambient PM_2.5 on HRV. We searched electronic databases (PubMed, Web of Science, and Embase) to identify panel studies reporting the associations between exposure to PM_2.5 and the four indicators of HRV (standard deviation of all normal-to-normal intervals (SDNN), root mean square of successive differences in adjacent normal-to-normal intervals (rMSSD), high frequency power (HF), and low frequency power (LF)). Random-effects model was used to calculate the pooled effect estimates.

Results

A total of 33 panel studies were included in our meta-analysis, with 16 studies conducted in North America, 12 studies in Asia, and 5 studies in Europe. The pooled results showed a 10 ?g/m³ increase in PM_2.5 exposure which was significantly associated with a -?0.92% change in SDNN (95% confidence intervals (95%CI) -?1.26%, -?0.59%), -?1.47% change in rMSSD (95%CI -?2.17%, -?0.77%), -?2.17% change in HF (95%CI -?3.24%, -?1.10%), and -?1.52% change in LF (95%CI -?2.50%, -?0.54%), respectively. Overall, subgroup analysis suggested that short-term exposure to PM_2.5 was associated with lower HRV levels in Asians, healthy population, and those aged ??40 years.

Conclusion

Short-term exposure to PM_2.5 was associated with decreased HRV levels. Future studies are warranted to clarity the exact mechanism of exposure to PM_2.5 on the cardiovascular system through disturbance of autonomic nervous function.

SUBMITTER: Niu Z

PROVIDER: S-EPMC7706193 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Acute effect of ambient fine particulate matter on heart rate variability: an updated systematic review and meta-analysis of panel studies.

Niu Zhiping Z Liu Feifei F Li Baojing B Li Na N Yu Hongmei H Wang Yongbo Y Tang Hong H Chen Xiaolu X Lu Yuanan Y Cheng Zilu Z Liu Suyang S Chen Gongbo G Zhang Yuxiao Y Xiang Hao H

Environmental health and preventive medicine 20201201 1

<h4>Background</h4>Decreased heart rate variability (HRV) is a predictor of autonomic system dysfunction, and is considered as a potential mechanism of increased risk of cardiovascular disease (CVD) induced by exposure to particulate matter less than 2.5 μm in diameter (PM<sub>2.5</sub>). Previous studies have suggested that exposure to PM<sub>2.5</sub> may lead to decreased HRV levels, but the results remain inconsistent.<h4>Methods</h4>An updated systematic review and meta-analysis of panel st ...[more]

PMID: 33261557

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Project description:Background/objectivePoor air quality is implicated as a risk factor for cognitive impairment and dementia. Few studies have examined these associations longitudinally in well-characterized population-based cohorts with standardized annual assessment of both mild cognitive impairment (MCI) and dementia. We investigated the association between estimated ambient fine particulate matter (PM2.5 ) and risk of incident MCI and dementia in a post-industrial region known for historically poor air quality.Setting/participantsAdults aged 65+ years in a population-based cohort (n = 1572).MeasurementsCensus tract level PM2.5 from Environmental Protection Agency (EPA) air quality monitors; Clinical Dementia Rating (CDR)®.DesignWe estimated ambient PM2.5 exposure (μg/m3 , single-year and 5-year averages) by geocoding participants' residential addresses to census tracts with daily EPA PM2.5 measurements from 2002 to 2014. Using Bayesian spatial regression modeling adjusted for age, sex, education, smoking history, and household income, we examined the association between estimated PM2.5 exposure and risk of incident MCI (CDR = 0.5) and incident dementia (CDR ≥ 1.0).ResultsModeling estimated single-year exposure, each 1 μg/m3 higher ambient PM2.5 was associated with 67% higher adjusted risk of incident dementia (hazard ratio [HR] = 1.669, 95% credible interval [CI]: 1.298, 2.136) and 75% higher adjusted risk of incident MCI (HR = 1.746, 95% CI: 1.518, 2.032). Estimates were higher when modeling 5-year ambient PM2.5 exposure for incident dementia (HR = 2.082, 95% CI: 1.528, 3.015) and incident MCI (HR = 3.419, 95% CI: 2.806, 4.164).ConclusionsHigher estimated ambient PM2.5 was associated with higher risk of incident MCI and dementia, particularly when considering longer-term exposure, and independent of demographic characteristics and smoking history. Targeting poor air quality may be a reasonable population-wide intervention to reduce the risk of cognitive impairment in older adults, particularly in regions exceeding current recommendations for safe exposure to PM2.5 .

Dataset Information

Acute effect of ambient fine particulate matter on heart rate variability: an updated systematic review and meta-analysis of panel studies.

Background

Methods

Results

Conclusion

Publications

Acute effect of ambient fine particulate matter on heart rate variability: an updated systematic review and meta-analysis of panel studies.

Similar Datasets

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