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Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

SUBMITTER: Lau SKP

PROVIDER: S-EPMC7706959 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells.

Lau Susanna K P SKP Wong Antonio C P ACP Luk Hayes K H HKH Li Kenneth S M KSM Fung Joshua J He Zirong Z Cheng Flora K K FKK Chan Tony T Y TTY Chu Stella S Aw-Yong Kam Leng KL Lau Terrence C K TCK Fung Kitty S C KSC Woo Patrick C Y PCY

Emerging infectious diseases 20200730 12

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism. ...[more]

PMID: 32730733

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