Ontology highlight
ABSTRACT:
SUBMITTER: Tzoumas N
PROVIDER: S-EPMC7707100 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Tzoumas Nikolaos N Farrah Tariq E TE Dhaun Neeraj N Webb David J DJ
British journal of pharmacology 20200204 24
PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the inhibition of cGMP degradation. Although these agents were originally developed for the treatment of hypertension and angina, unanticipated side effects led to advances in the treatment of erectile dysfunction and, later, pulmonary arterial hypertension. In the last decade, accumulating evidence suggests that PDE ...[more]