Ontology highlight
ABSTRACT:
SUBMITTER: Kukreja RC
PROVIDER: S-EPMC3206106 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Kukreja Rakesh C RC Salloum Fadi N FN Das Anindita A Koka Saisudha S Ockaili Ramzi A RA Xi Lei L
Experimental and clinical cardiology 20110101 4
Phosphodiesterase type-5 (PDE-5) is an enzyme that catalyzes the hydrolytic degradation of cyclic GMP - an essential intracellular second messenger that modulates diverse biological processes in living cells. Three selective inhibitors of PDE-5 - sildenafil, vardenafil and tadalafil - have been successfully used by millions of men worldwide for the treatment of erectile dysfunction. Also, sildenafil and tadalafil are currently approved for the treatment of pulmonary hypertension. Recent powerful ...[more]