Ontology highlight
ABSTRACT:
SUBMITTER: Han M
PROVIDER: S-EPMC7708066 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Han Mengmeng M Li Jialun J Cao Yaqiang Y Huang Yuanyong Y Li Wen W Zhu Haijun H Zhao Qian Q Han Jing-Dong Jackie JJ Wu Qihan Q Li Jiwen J Feng Jing J Wong Jiemin J
Nucleic acids research 20201201 21
LSH, a SNF2 family DNA helicase, is a key regulator of DNA methylation in mammals. How LSH facilitates DNA methylation is not well defined. While previous studies with mouse embryonic stem cells (mESc) and fibroblasts (MEFs) derived from Lsh knockout mice have revealed a role of Lsh in de novo DNA methylation by Dnmt3a/3b, here we report that LSH contributes to DNA methylation in various cell lines primarily by promoting DNA methylation by DNMT1. We show that loss of LSH has a much bigger effect ...[more]