Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC6753495 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhang Huifang H Gao Qinqin Q Tan Shuo S You Jia J Lyu Cong C Zhang Yunpeng Y Han Mengmeng M Chen Zhaosu Z Li Jialun J Wang Hailin H Liao Lujian L Qin Jun J Li Jiwen J Wong Jiemin J
Nucleic acids research 20190901 17
Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8, a cell-cycle-regulated protein methyltransferase, controls protein stability of both UHRF1 and DNMT1 through methylation-mediated, ubiquitin-dependent degradation and consequently prevents excessive DNA methylation. SET8 methylates UHRF1 at lysine 385 and this modifi ...[more]