Dataset Information

Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease.

ABSTRACT: Bronchodilators, including long-acting ?₂-agonists and long-acting muscarinic antagonists, are the mainstay for treatment of patients with chronic obstructive pulmonary disease (COPD) to prevent exacerbations or reduce symptoms. Formoterol is a highly selective and potent ?₂-agonist that relaxes airway smooth muscle to significantly improve lung function. Inhaled formoterol works within 5 minutes of administration and provides improvements in spirometry measurements over 12 hours. The lipophilicity of formoterol allows it to form a depot within the smooth muscle to provide a prolonged duration of action. Following therapeutic doses, plasma concentrations are very low or undetectable. Determination of the pharmacokinetics of formoterol following high-dose administration to healthy volunteers revealed that the drug was rapidly absorbed and excreted unchanged in the urine with a half-life of 10 hours. Inhaled formoterol, as monotherapy or in combination with other agents, is an effective and safe treatment option for patients with moderate to severe COPD. Clinical studies have demonstrated improvements in lung function and COPD symptoms, particularly dyspnea; reductions in the risk of exacerbations; and improvement in patients' health status. The adverse event profile of inhaled formoterol is similar to that of placebo, with few adverse cardiovascular events. Formoterol is a valuable bronchodilator used in the maintenance treatment of COPD. This review describes the mechanism of action, pharmacodynamics, and pharmacokinetics of inhaled formoterol. It also reviews the results of large, randomized, controlled clinical trials that evaluated the use of formoterol as monotherapy and in combination with inhaled corticosteroids, long-acting muscarinic antagonists, and triple therapy regimens in the treatment of patients with moderate to severe COPD.

SUBMITTER: Tashkin DP

PROVIDER: S-EPMC7708267 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease.

Tashkin Donald P DP

International journal of chronic obstructive pulmonary disease 20201127

Bronchodilators, including long-acting β<sub>2</sub>-agonists and long-acting muscarinic antagonists, are the mainstay for treatment of patients with chronic obstructive pulmonary disease (COPD) to prevent exacerbations or reduce symptoms. Formoterol is a highly selective and potent β<sub>2</sub>-agonist that relaxes airway smooth muscle to significantly improve lung function. Inhaled formoterol works within 5 minutes of administration and provides improvements in spirometry measurements over 12 ...[more]

PMID: 33273813

Similar Datasets

Project description:'Clinically important deterioration' (CID) is a composite endpoint measuring worsening of the key clinical features of chronic obstructive pulmonary disease (COPD), namely lung function, patient-reported outcomes, and exacerbations. ACLIFORM and AUGMENT were two 24-week, randomized, double-blind, phase III studies assessing twice-daily (BID) aclidinium bromide (AB) 400 ?g/formoterol fumarate (FF) 12 ?g. This pooled post-hoc analysis assessed the effects of AB/FF 400/12 ?g on both first and sustained CID events versus placebo and monotherapies in patients with moderate to severe COPD.A first CID event was defined as the occurrence of a moderate/severe exacerbation or the worsening from baseline in ?1 of the following: trough forced expiratory volume in 1 second (FEV1; ?100 mL), Transition Dyspnea Index (TDI) focal score (?1 unit), or St George's Respiratory Questionnaire (SGRQ) total score (?4 units). A 'sustained' CID was defined as a worsening maintained at all subsequent visits from appearance to week 24 or a moderate/severe exacerbation at any time. CID events were assessed at three visits (weeks 4, 12, and 24); trough FEV1 was also measured at weeks 1 and 18.AB/FF 400/12 ?g reduced the risk of a first CID event by 45% versus placebo (hazard ratio [HR] 0.55, p?<?0.001), 18% versus FF 12 ?g (HR 0.82, p?<?0.01), and 15% versus AB 400 ?g (HR 0.85, p?<?0.05). Similarly, AB/FF 400/12 ?g reduced the risk of a sustained CID event by 48% versus placebo (HR 0.52, p?<?0.001) and 22% versus FF 12 ?g (HR 0.78, p?<?0.01). AB/FF 400/12 ?g reduced the risk of a first or sustained CID event for all four components versus placebo (trough FEV1 and TDI, first and sustained CID, all p?<?0.001; SGRQ first CID p?<?0.001; SGRQ sustained CID, p?<?0.01; exacerbations first and sustained CID, both p?<?0.05) and TDI and SGRQ versus FF 12 ?g (TDI, first and sustained CID both p?<?0.05; SGRQ first CID p?<?0.01), and SGRQ versus AB 400 ?g (first CID, p?<?0.05).AB/FF 400/12 ?g BID may provide greater airway stability and fewer exacerbations or deteriorations in lung function, health status, or dyspnea compared with placebo or monotherapies.Clinicaltrials.gov NCT01462942 (ACLIFORM); registered 26 October 2011. Clinicaltrials.gov NCT01437397 (AUGMENT); registered 19 September 2011.

Dataset Information

Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease.

Publications

Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets