Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC7708464 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Liu Xiufen X Chan Alexander A Tai Chin-Hsien CH Andresson Thorkell T Pastan Ira I
Communications biology 20201201 1
Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several different cancers. The restricted expression of MSLN in normal tissue and its frequent expression in cancers make MSLN an excellent target for antibody-based therapies. Many clinical trials with agents targeting MSLN have been carried out but to date none of these agents have produced enough responses to obtain FDA approval. M ...[more]