Ontology highlight
ABSTRACT:
SUBMITTER: Zhang HG
PROVIDER: S-EPMC7709827 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Oncology reports 20201026 1
Long non‑coding RNA growth arrest specific 5 (GAS5) exerts inhibitory effects through the modulation of several target microRNAs (miRs) in cancer. However, its potential roles and underlying relationship during colorectal cancer (CRC) progression are unclear. Therefore, we explored the role of the negative feedback loop formed by the GAS5/miR‑34a axis and mammalian target of rapamycin/sirtuin 1 (mTOR/SIRT1) pathway on macroautophagy and apoptosis in CRC. Expression of GAS5, miR‑34a, SIRT1 and mT ...[more]