Ontology highlight
ABSTRACT:
SUBMITTER: Jia Z
PROVIDER: S-EPMC7709973 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Jia Zhihao Z Yue Feng F Chen Xiyue X Narayanan Naagarajan N Qiu Jiamin J Syed Sabriya A SA Imbalzano Anthony N AN Deng Meng M Yu Peng P Hu Changdeng C Kuang Shihuan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20201016 23
The protein arginine methyltransferase 5 (PRMT5) is an emerging regulator of cancer and stem cells including adipogenic progenitors. Here, a new physiological role of PRMT5 in adipocytes and systemic metabolism is reported. Conditional knockout mice were generated to ablate the <i>Prmt5</i> gene specifically in adipocytes (Prmt5<sup>AKO</sup>). The Prmt5<sup>AKO</sup> mice exhibit sex- and depot-dependent progressive lipodystrophy that is more pronounced in females and in visceral (than subcutan ...[more]