Ontology highlight
ABSTRACT:
SUBMITTER: Yang QK
PROVIDER: S-EPMC7710422 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yang Qian-Kun QK Wang Xue-Xin XX Wang Yang Y Ni Ni N
Journal of oncology 20201124
Inside the cancer microenvironment, reduced O<sub>2</sub> concentration, termed as hypoxia, is a common phenotype and leads to cancer progression. However, little is known about how and when those HIF members are dysregulated in distinct cancers. Here, by integrating a full range of data of thousands of patients, we comprehensively analyzed the genetics, epigenetics, and transcriptomic level of HIF genes and further defined pathways triggered by disrupted hypoxia-inducible factors. We reveal the ...[more]