Ontology highlight
ABSTRACT:
SUBMITTER: Benita Y
PROVIDER: S-EPMC2724271 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Benita Yair Y Kikuchi Hirotoshi H Smith Andrew D AD Zhang Michael Q MQ Chung Daniel C DC Xavier Ramnik J RJ
Nucleic acids research 20090602 14
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the transcriptional response to oxygen flux. To gain insight into the molecular pathways regulated by HIF-1, it is essential to identify the downstream-target genes. We report here a strategy to identify HIF-1-target genes based on an integrative genomic approach combining computational strategies and experimental validation. To identify HIF-1-target genes microarrays data sets were used to rank genes based on th ...[more]