Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity.

ABSTRACT: Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental area (VTA), supporting food seeking. The activity of VTA dopamine neurons increases significantly after administration of intragastric sucrose, and deletion of the NMDA receptor in these neurons, which affects bursting and plasticity, abolishes lever pressing for postingestive sucrose delivery. Furthermore, lesions of the hepatic branch of the vagus nerve significantly impair postingestive-dependent VTA dopamine neuron activity and food seeking, whereas optogenetic stimulation of left v

SUBMITTER: Fernandes AB 

PROVIDER: S-EPMC7710496 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature