Ontology highlight
ABSTRACT:
SUBMITTER: Huh JY
PROVIDER: S-EPMC7710607 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Huh Jin Young JY Reilly Shannon M SM Abu-Odeh Mohammad M Murphy Anne N AN Mahata Sushil K SK Zhang Jinyu J Cho Yoori Y Seo Jong Bae JB Hung Chao-Wei CW Green Courtney R CR Metallo Christian M CM Saltiel Alan R AR
Cell metabolism 20201104 6
Hepatic TANK (TRAF family member associated NFκB activator)-binding kinase 1 (TBK1) activity is increased during obesity, and administration of a TBK1 inhibitor reduces fatty liver. Surprisingly, liver-specific TBK1 knockout in mice produces fatty liver by reducing fatty acid oxidation. TBK1 functions as a scaffolding protein to localize acyl-CoA synthetase long-chain family member 1 (ACSL1) to mitochondria, which generates acyl-CoAs that are channeled for β-oxidation. TBK1 is induced during fas ...[more]