Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee A
PROVIDER: S-EPMC7711289 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
iScience 20201120 12
Multiple sclerosis (MS) is a demyelinating disease caused by an auto-reactive immune system. Recent studies also demonstrated synapse dysfunctions in MS patients and MS mouse models. We previously observed decreased synaptic vesicle exocytosis in photoreceptor synapses in the EAE mouse model of MS at an early, preclinical stage. In the present study, we analyzed whether synaptic defects are associated with altered presynaptic Ca<sup>2+</sup> signaling. Using high-resolution immunolabeling, we fo ...[more]