Ontology highlight
ABSTRACT:
SUBMITTER: Holubova J
PROVIDER: S-EPMC7711433 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Holubová Jana J Staněk Ondřej O Brázdilová Ludmila L Mašín Jiří J Bumba Ladislav L Gorringe Andrew R AR Alexander Frances F Šebo Peter P
Vaccines 20201119 4
<i>Bordetella pertussis</i> whole-cell vaccines (wP) caused a spectacular drop of global pertussis incidence, but since the replacement of wP with acellular pertussis vaccines (aP), pertussis has resurged in developed countries within 7 to 12 years of the change from wP to aP. In the mouse infection model, we examined whether addition of further protective antigens into the aP vaccine, such as type 2 and type 3 fimbriae (FIM2/3) with outer membrane lipooligosaccharide (LOS) and/or of the adenyla ...[more]