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Proteomics of Bordetella pertussis whole-cell and acellular vaccines.

ABSTRACT: OBJECTIVES:Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host-pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry. DATA DESCRIPTION:LC-MS/MS spectra were generated and analyzed using B. pertussis genome data and proteins present in whole-cell and acellular pertussis vaccines were identified. Subcellular localization of proteins and presence of signal peptides was determined bioinformatically.

SUBMITTER: Moller J

PROVIDER: S-EPMC6558669 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Proteomics of Bordetella pertussis whole-cell and acellular vaccines.

Möller Jens J Kraner Max Edmund ME Burkovski Andreas A

BMC research notes 20190610 1

<h4>Objectives</h4>Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host-pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry.<h4>Data description</h4>LC-MS/MS ...[more]

PMID: 31182148

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Proteomics of Bordetella pertussis whole-cell and acellular vaccines

Project description:Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host-pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry.

2019-05-14 | PXD013804 | Pride

Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines.

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| S-EPMC5994715 | biostudies-literature

Different effects of whole-cell and acellular vaccines on Bordetella transmission.

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<i>Bordetella pertussis</i> Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naive Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice.

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| S-EPMC6200895 | biostudies-literature

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