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Novel 4,6-Disubstituted s-Triazin-2-yl Amino Acid Derivatives as Promising Antifungal Agents.

ABSTRACT: A novel series of 4,6-disubstituted s-triazin-2-yl amino acid derivatives was prepared and characterized. Most of them showed antifungal activity against Candida albicans compared to clotrimazole (standard drug). Compounds bearing aniline derivatives, piperidine and glycine on the triazine core showed the highest inhibition zones at concentrations of 50, 100, 200, and 300 ?g per disc. In addition, docking studies revealed that all the compounds accommodated well in the active site residues of N-myristoltransferase (NMT) and exhibited complementarity, which explains the observed antifungal activity. Interestingly, none of these compounds showed antibacterial activity.

SUBMITTER: Abd Alhameed R

PROVIDER: S-EPMC7712924 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Novel 4,6-Disubstituted s-Triazin-2-yl Amino Acid Derivatives as Promising Antifungal Agents.

Abd Alhameed Rakia R Almarhoon Zainab Z N Sholkamy Essam E Ali Khan Salman S Ul-Haq Zaheer Z Sharma Anamika A G de la Torre Beatriz B Albericio Fernando F El-Faham Ayman A

Journal of fungi (Basel, Switzerland) 20201021 4

A novel series of 4,6-disubstituted s-triazin-2-yl amino acid derivatives was prepared and characterized. Most of them showed antifungal activity against Candida albicans compared to clotrimazole (standard drug). Compounds bearing aniline derivatives, piperidine and glycine on the triazine core showed the highest inhibition zones at concentrations of 50, 100, 200, and 300 μg per disc. In addition, docking studies revealed that all the compounds accommodated well in the active site ...[more]

PMID: 33096851

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