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ABSTRACT: Objective
To examine in vivo amyloid burden in relation to APOEε4 genotype in middle-aged Hispanics. We hypothesize higher amyloid levels among APOE ε4 carriers vs APOE ε4 noncarriers.Methods
This is a cross-sectional study in a community-based sample of 249 middle-aged Hispanics in New York City who underwent a 3T brain MRI and PET with the amyloid radioligand 18F-florbetaben. APOE genotype was the primary exposure. The primary outcome was amyloid positivity. The secondary outcome was subthreshold amyloid levels examined as a continuous variable.Results
APOE ε4 carriers (n = 85) had a higher frequency (15.3%) of amyloid positivity compared to APOE ε4 noncarriers (n = 164, 1.8%). In the subthreshold group of amyloid-negative participants (n = 233), APOE ε4 carriers (n = 72) had a 0.02 (95% confidence interval [CI] 0.01-0.04) higher global brain amyloid standardized uptake value ratio (SUVR) compared to APOE ε4 noncarriers (n = 161). Compared to participants with the ε3/ε3 genotype, participants with ε4/ε4 had the highest frequency of amyloid positivity (28.6%), followed by those with ε3/ε4 (11%). Among amyloid-negative participants (n = 233), compared to participants with ε3/ε3 (n = 134), those with ε4/ε4 (n = 5) had a 0.12 (95% CI 0.07-0.17) higher global brain amyloid SUVR, and those with ε3/ε4 had a 0.02 higher SUVR (95% CI 0.003-0.04). Results were similar when a median split was used for elevated amyloid, when continuous amyloid SUVR was analyzed in all participants, and in nonparametric Mann-Whitney comparisons.Conclusion
Middle-aged Hispanic APOE ε4 carriers have higher in vivo brain amyloid burden compared with noncarriers, as reported in non-Hispanics.
SUBMITTER: Palta P
PROVIDER: S-EPMC7713748 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Palta Priya P Rippon Brady B Reitz Christiane C He Hengda H Sherwood Greysi G Ceballos Fernando F Teresi Jeanne J Razlighi Qolamreza Q Moreno Herman H Brickman Adam M AM Luchsinger José A JA
Neurology 20200826 15
<h4>Objective</h4>To examine in vivo amyloid burden in relation to <i>APOE</i>ε4 genotype in middle-aged Hispanics. We hypothesize higher amyloid levels among <i>APOE ε4</i> carriers vs <i>APOE ε4</i> noncarriers.<h4>Methods</h4>This is a cross-sectional study in a community-based sample of 249 middle-aged Hispanics in New York City who underwent a 3T brain MRI and PET with the amyloid radioligand <sup>18</sup>F-florbetaben. <i>APOE</i> genotype was the primary exposure. The primary outcome was ...[more]