Ontology highlight
ABSTRACT:
SUBMITTER: Lopresti BJ
PROVIDER: S-EPMC7483397 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lopresti Brian J BJ Campbell Elizabeth M EM Yu Zheming Z Anderson Stewart J SJ Cohen Ann D AD Minhas Davneet S DS Snitz Beth E BE Royse Sarah K SK Becker Carl R CR Aizenstein Howard J HJ Mathis Chester A CA Lopez Oscar L OL Klunk William E WE Tudorascu Dana L DL
Neurobiology of aging 20200531
To characterize the influence of apolipoprotein-E (APOE) genotype on cerebral Aβ load and longitudinal Aβ trajectories, [<sup>11</sup>C]Pittsburgh compound-B (PiB) positron emission tomography (PET) imaging was used to assess amyloid load in a clinically heterogeneous cohort of 428 elderly participants with known APOE genotype. Serial [<sup>11</sup>C]PiB data and a repeated measures model were used to model amyloid trajectories in a subset of 235 participants classified on the basis of APOE geno ...[more]