Comparison of subtyping methods for neuroimaging studies in Alzheimer's disease: a call for harmonization.

ABSTRACT: Biological subtypes in Alzheimer's disease, originally identified on neuropathological data, have been translated to in vivo biomarkers such as structural magnetic resonance imaging and positron emission tomography, to disentangle the heterogeneity within Alzheimer's disease. Although there is methodological variability across studies, comparable characteristics of subtypes are reported at the group level. In this study, we investigated whether group-level similarities translate to individual-level agreement across subtyping methods, in a head-to-head context. We compared five previously published subtyping methods. Firstly, we validated the subtyping methods in 89 amyloid-beta positive Alzheimer's disease dementia patients (reference group: 70 amyloid-beta negative healthy individu

SUBMITTER: Mohanty R 

PROVIDER: S-EPMC7713995 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature