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Measles virus and rinderpest virus divergence dated to the sixth century BCE.

ABSTRACT: Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. Although it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. We sequenced the genome of a 1912 measles virus and used selection-aware molecular clock modeling to determine the divergence date of measles virus and rinderpest virus. This divergence date represents the earliest possible date for the establishment of measles in human populations. Our analyses show that the measles virus potentially arose as early as the sixth century BCE, possibly coinciding with the rise of large cities.

SUBMITTER: Dux A

PROVIDER: S-EPMC7713999 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Measles virus and rinderpest virus divergence dated to the sixth century BCE.

Düx Ariane A Lequime Sebastian S Patrono Livia Victoria LV Vrancken Bram B Boral Sengül S Gogarten Jan F JF Hilbig Antonia A Horst David D Merkel Kevin K Prepoint Baptiste B Santibanez Sabine S Schlotterbeck Jasmin J Suchard Marc A MA Ulrich Markus M Widulin Navena N Mankertz Annette A Leendertz Fabian H FH Harper Kyle K Schnalke Thomas T Lemey Philippe P Calvignac-Spencer Sébastien S

Science (New York, N.Y.) 20200601 6497

Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. Although it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. We sequenced the genome of a 1912 measles virus and used selection-aware molecular clock modeling to determine the divergence date of measles virus and rinderpest virus. This divergence date represents the earliest possible date for the establishment of measles in human popu ...[more]

PMID: 32554594

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