Ontology highlight
ABSTRACT:
SUBMITTER: Gazit VA
PROVIDER: S-EPMC7714413 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Gazit Vered A VA Swietlicki Elzbieta A EA Liang Miranda U MU Surti Adam A McDaniel Raechel R Geisman Mackenzie M Alvarado David M DM Ciorba Matthew A MA Bochicchio Grant G Ilahi Obeid O Kirby John J Symons William J WJ Davidson Nicholas O NO Levin Marc S MS Rubin Deborah C DC
JCI insight 20201203 23
Loss of functional small bowel surface area following surgical resection for disorders such as Crohn's disease, intestinal ischemic injury, radiation enteritis, and in children, necrotizing enterocolitis, atresia, and gastroschisis, may result in short bowel syndrome, with attendant high morbidity, mortality, and health care costs in the United States. Following resection, the remaining small bowel epithelium mounts an adaptive response, resulting in increased crypt cell proliferation, increased ...[more]