Dataset Information
Nonselective Compared With Selective ?-Blockade Is Associated With Less Intraoperative Hypertension in Patients With Pheochromocytomas and Paragangliomas: A Retrospective Cohort Study With Propensity Score Matching.
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ABSTRACT:
Methods: In this propensity-matched retrospective cohort study, data of patients who received either selective or nonselective ?-blockade preoperatively and underwent surgery for PPGLs were collected. The primary end point was the time-weighted average above the systolic blood pressure (SBP) of 160 mm Hg (TWA-SBP >160 mm Hg), which was calculated as the total area of the SBP-time curve above the SBP of 160 mm Hg and divided by anesthesia duration.
Results: A total of 286 patients were included in analysis; of them, 156 received selective ?-blockade and 130 nonselective ?-blockade. After propensity score matching, 89 patients remained in each group. Patients who received nonselective ?-blockade had a lower TWASBP >160 (median 0.472 mm Hg, interquartile range [IQR], 0.081-1.300) versus those who received selective ?-blockade (median 1.114 mm Hg, IQR, 0.162-2.853; median difference -0.391, 95% confidence interval [CI], -0.828 to -0.032; P = .016); they also had a lower highest SBP during surgery (193 ± 24 mm Hg versus 205 ± 34 mm Hg; mean difference -12, 95% CI, -20 to -3; P = .008). Postoperative outcomes did not differ significantly between the 2 groups.
Conclusions: For patients undergoing surgery for PPGLs, preoperative nonselective ?-blockade was associated with less intraoperative hypertension when compared with selective ?-blockade.
SUBMITTER: Kong H
PROVIDER: S-EPMC7717474 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Nonselective Compared With Selective α-Blockade Is Associated With Less Intraoperative Hypertension in Patients With Pheochromocytomas and Paragangliomas: A Retrospective Cohort Study With Propensity Score Matching.
Anesthesia and analgesia 20210101 1
<h4>Background</h4>Both selective and nonselective α-blockade are used for preoperative preparation in patients with pheochromocytomas and paragangliomas (PPGLs). However, the effects of different types of α-blockade on perioperative outcomes remain inconclusive. This study was designed to assess the association between the choice of α-blockade and the amount of intraoperative hypertension in patients undergoing surgery for PPGLs.<h4>Methods</h4>In this propensity-matched retrospective cohort st ...[more]