Understanding racial disparities in renal cell carcinoma incidence: estimates of population attributable risk in two US populations.

ABSTRACT:

Purpose

Renal cell carcinoma (RCC) incidence is higher among black than white Americans. The reasons for this disparity remain unclear.

Methods

We calculated race- and sex-specific population attributable risk percentages (PAR%) and their 95% confidence intervals (CI) for hypertension and chronic kidney disease (CKD) among black and white subjects ≥  50 years of age from the US Kidney Cancer Study (USKC; 965 cases, 953 controls), a case-control study in Chicago and Detroit, and a nested case-control study in the Kaiser Permanente Northern California health care network (KPNC; 2,162 cases, 21,484 controls). We also estimated PAR% for other modifiable RCC risk factors (cigarette smoking, obesity) in USKC.

Results

In USKC, the PAR% for hypertension was 50% (95% CI 24-77%

SUBMITTER: Callahan CL 

PROVIDER: S-EPMC7717618 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature