Unknown

Dataset Information

0

Application of MR diffusion imaging for non-invasive assessment of acute kidney injury after lung transplantation.


ABSTRACT: To assess whether MR diffusion imaging may be applied for non-invasive detection of renal changes correlating with clinical diagnosis of acute kidney injury (AKI) in patients after lung transplantation (lutx).Fifty-four patients (mean age 49.6, range 26-64 years) after lutx were enrolled in a prospective clinical study and underwent functional MR imaging of the kidneys in the early postoperative period. Baseline s-creatinine ranged from 39 to 112??mol/L. For comparison, 14 healthy volunteers (mean age 42.1, range 24-59 years) underwent magnetic resonance imaging (MRI) using the same protocol. Renal tissue injury was evaluated using quantification of diffusion and diffusion anisotropy with diffusion-weighted (DWI) and diffusion-tensor imaging (DTI). Renal function was monitored and AKI was defined according to Acute-Kidney-Injury-Network criteria. Statistical analysis comprised one-way ANOVA and Pearson correlation.67% of lutx patients (36/54) developed AKI, 47% (17/36) had AKI stage 1, 42% (15/36) AKI stage 2, and 8% (3/36) severe AKI stage 3. Renal apparent diffusion coefficients (ADCs) were reduced in patients with AKI, but preserved in transplant patients without AKI and healthy volunteers (2.07?±?0.02 vs 2.18?±?0.05 vs 2.21?±?0.03?×?10?mm/s, P?

SUBMITTER: Derlin K 

PROVIDER: S-EPMC7717793 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


To assess whether MR diffusion imaging may be applied for non-invasive detection of renal changes correlating with clinical diagnosis of acute kidney injury (AKI) in patients after lung transplantation (lutx).Fifty-four patients (mean age 49.6, range 26-64 years) after lutx were enrolled in a prospective clinical study and underwent functional MR imaging of the kidneys in the early postoperative period. Baseline s-creatinine ranged from 39 to 112 μmol/L. For comparison, 14 healthy volunteers (me  ...[more]

Similar Datasets

| S-EPMC7290480 | biostudies-literature
| S-EPMC4734159 | biostudies-literature
| S-EPMC5530196 | biostudies-other
| S-EPMC6033396 | biostudies-literature
| S-EPMC6803785 | biostudies-literature
| S-EPMC4295209 | biostudies-literature
| S-EPMC3009378 | biostudies-literature
| S-EPMC5548514 | biostudies-other
| S-EPMC6833042 | biostudies-literature
| S-EPMC8028790 | biostudies-literature