The Impact of ¹⁸F-DCFPyL PET-CT Imaging on Initial Staging, Radiation, and Systemic Therapy Treatment Recommendations for Veterans With Aggressive Prostate Cancer.

ABSTRACT: Purpose: Our purpose was to study the effect of 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (¹⁸F-DCFPyL) positron emission tomography (PET)-computed tomography (CT) on staging/treatment recommendations of previously untreated prostate cancer. We report here results of a prospective single center single arm imaging trial within Veterans Affairs (Greater Los Angeles): the frequency of patients upstaged to M1 disease (primary endpoint) and the frequency of patients with change in treatment recommendations (secondary endpoint). This is the first report of prostate-specific membrane antigen PET-CT exclusive to U.S. veterans.

Methods and materials: Veterans with Gleason ?4 + 3, clinical stage ?T2c, or prostate-specific antigen >10 ng/mL were eligible. Patients underwent conventional imaging (^99mTc-methyl diphosphonate bone scan or ¹⁸F-NaF PET-CT; and pelvic CT or pelvic magnetic resonance imaging) in addition to ¹⁸F-DCFPyL PET-CT. The effect of ¹⁸F-DCFPyL PET-CT on treatment change was determined by applying prespecified treatment recommendations based on National Comprehensive Cancer Network guidelines and modern clinical practice.

Results: One hundred patients underwent ¹⁸F-DCFPyL PET-CT. Nineteen out of 84 (23%) patients initially thought to be nonmetastatic were upstaged to M1; 8/16 (50%) patients initially thought to have M1 disease were downstaged to M0. In total, 39/100 (39%) had a change in prespecified treatment recommendations, including change of radiation therapy volume/dose in 39/100 (39%) and starting abiraterone in 22/100 (22%).

Conclusions: Incorporation of ¹⁸F-DCFPyL PET-CT into the initial conventional imaging workup for prostate cancer can substantially affect staging/treatment recommendations.

SUBMITTER: Parikh NR 

PROVIDER: S-EPMC7718503 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature