Ontology highlight
ABSTRACT:
SUBMITTER: Fan Z
PROVIDER: S-EPMC7719152 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Fan Ze Z Zhang Zhihao Z Zhao Shiyi S Zhu Yuanyuan Y Guo Dong D Yang Bo B Zhuo Lixia L Han Jiao J Wang Rui R Fang Zongping Z Dong Hailong H Li Yan Y Xiong Lize L
Neuroscience bulletin 20201013 12
General anesthesia severely affects the metabolites in the brain. Glycogen, principally stored in astrocytes and providing the short-term delivery of substrates to neurons, has been implicated as an affected molecule. However, whether glycogen plays a pivotal role in modulating anesthesia-arousal remains unclear. Here, we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes in the glycogen levels in various brain regions. Glycogen synthase (GS) and glycogen phosphorylase (GP) ...[more]