Ontology highlight
ABSTRACT:
SUBMITTER: Mazewski C
PROVIDER: S-EPMC7719805 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Mazewski Candice C Perez Ricardo E RE Fish Eleanor N EN Platanias Leonidas C LC
Frontiers in immunology 20201123
For several decades there has been accumulating evidence implicating type I interferons (IFNs) as key elements of the immune response. Therapeutic approaches incorporating different recombinant type I IFN proteins have been successfully employed to treat a diverse group of diseases with significant and positive outcomes. The biological activities of type I IFNs are consequences of signaling events occurring in the cytoplasm and nucleus of cells. Biochemical events involving JAK/STAT proteins tha ...[more]