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RNA control in pain: Blame it on the messenger.

ABSTRACT: mRNA function is meticulously controlled. We provide an overview of the integral role that posttranscriptional controls play in the perception of painful stimuli by sensory neurons. These specialized cells, termed nociceptors, precisely regulate mRNA polarity, translation, and stability. A growing body of evidence has revealed that targeted disruption of mRNAs and RNA-binding proteins robustly diminishes pain-associated behaviors. We propose that the use of multiple independent regulatory paradigms facilitates robust temporal and spatial precision of protein expression in response to a range of pain-promoting stimuli. This article is categorized under: RNA in Disease and Development > RNA in Disease Translation > Translation Regulation RNA Turnover and Surveillance > Regulation of RNA Stability.

SUBMITTER: de la Pena JBI

PROVIDER: S-EPMC7721054 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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RNA control in pain: Blame it on the messenger.

de la Peña June Bryan I JBI Song Jane J JJ Campbell Zachary T ZT

Wiley interdisciplinary reviews. RNA 20190514 6

mRNA function is meticulously controlled. We provide an overview of the integral role that posttranscriptional controls play in the perception of painful stimuli by sensory neurons. These specialized cells, termed nociceptors, precisely regulate mRNA polarity, translation, and stability. A growing body of evidence has revealed that targeted disruption of mRNAs and RNA-binding proteins robustly diminishes pain-associated behaviors. We propose that the use of multiple independent regulatory paradi ...[more]

PMID: 31090211

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