NOX2-Derived Reactive Oxygen Species in Cancer.
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ABSTRACT:
SUBMITTER: Grauers Wiktorin H
PROVIDER: S-EPMC7721506 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
NOX2-Derived Reactive Oxygen Species in Cancer.
Grauers Wiktorin Hanna H Aydin Ebru E Hellstrand Kristoffer K Martner Anna A
Oxidative medicine and cellular longevity 20201127
The formation of reactive oxygen species (ROS) by the myeloid cell NADPH oxidase NOX2 is critical for the destruction of engulfed microorganisms. However, recent studies imply that ROS, formed by NOX2<sup>+</sup> myeloid cells in the malignant microenvironment, exert multiple actions of relevance to the growth and spread of neoplastic cells. By generating ROS, tumor-infiltrating myeloid cells and NOX2<sup>+</sup> leukemic myeloid cells may thus (i) compromise the function and viability of adjace ...[more]
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