Dataset Information

Impact of the dosimetry approach on the resulting ⁹⁰Y radioembolization planned absorbed doses based on ^99mTc-MAA SPECT-CT: is there agreement between dosimetry methods?

ABSTRACT:

Background

Prior radioembolization, a simulation using ^99mTc-macroaggregated albumin as ⁹⁰Y-microspheres surrogate is performed. Gamma scintigraphy images (planar, SPECT, or SPECT-CT) are acquired to evaluate intrahepatic ⁹⁰Y-microspheres distribution and detect possible extrahepatic and lung shunting. These images may be used for pre-treatment dosimetry evaluation to calculate the ⁹⁰Y activity that would get an optimal tumor response while sparing healthy tissues. Several dosimetry methods are available, but there is still no consensus on the best methodology to calculate absorbed doses. The goal of this study was to retrospectively evaluate the impact of using different dosimetry approaches on the resulting ⁹⁰Y-radioembolization pre-treatment absorbed dose evaluation based on ^99mTc-MAA images.

Methods

Absorbed doses within volumes of interest resulting from partition model (PM) and 3D voxel dosimetry methods (3D-VDM) (dose-point kernel convolution and local deposition method) were evaluated. Additionally, a new "Multi-tumor Partition Model" (MTPM) was developed. The differences among dosimetry approaches were evaluated in terms of mean absorbed dose and dose volume histograms within the volumes of interest.

Results

Differences in mean absorbed dose among dosimetry methods are higher in tumor volumes than in non-tumoral ones. The differences between MTPM and both 3D-VDM were substantially lower than those observed between PM and any 3D-VDM. A poor correlation and concordance were found between PM and the other studied dosimetry approaches. DVH obtained from either 3D-VDM are pretty similar in both healthy liver and individual tumors. Although no relevant global differences, in terms of absorbed dose in Gy, between both 3D-VDM were found, important voxel-by-voxel differences have been observed.

Conclusions

Significant differences among the studied dosimetry approaches for ⁹⁰Y-radioembolization treatments exist. Differences do not yield a substantial impact in treatment planning for healthy tissue but they do for tumoral liver. An individual segmentation and evaluation of the tumors is essential. In patients with multiple tumors, the application of PM is not optimal and the 3D-VDM or the new MTPM are suggested instead. If a 3D-VDM method is not available, MTPM is the best option. Furthermore, both 3D-VDM approaches may be indistinctly used.

SUBMITTER: Moran V

PROVIDER: S-EPMC7721939 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Impact of the dosimetry approach on the resulting 90Y radioembolization planned absorbed doses based on 99mTc-MAA SPECT-CT: is there agreement between dosimetry methods?

Morán Verónica V Prieto Elena E Sancho Lidia L Rodríguez-Fraile Macarena M Soria Leticia L Zubiria Arantxa A Martí-Climent Josep M JM

EJNMMI physics 20201207 1

<h4>Background</h4>Prior radioembolization, a simulation using 99mTc-macroaggregated albumin as 90Y-microspheres surrogate is performed. Gamma scintigraphy images (planar, SPECT, or SPECT-CT) are acquired to evaluate intrahepatic 90Y-microspheres distribution and detect possible extrahepatic and lung shunting. These images may be used for pre-treatment dosimetry evaluation to calculate the 90Y activity that would get an optimal tumor response while spa ...[more]

PMID: 33284389

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