Dataset Information

Assessing Spatial Concordance Between Theranostic Pairs Using Phantom and Patient-Specific Acceptance Criteria: Application to ^99mTc-MAA SPECT/⁹⁰Y-Microsphere PET.

ABSTRACT:

Purpose

Predictive 3-dimensional dosimetry requires spatial concordance between diagnostic and therapeutic activity distributions. We assess similarity between theranostic pairs (^99mTc-macroaggregated albumin [MAA] single photon emission computed tomography [SPECT] and ⁹⁰Y microsphere positron emission tomography [PET]) in patients using criteria that account for spatial resolution differences and misregistration.

Methods and materials

Phantom-based acceptance criteria were determined using a liver phantom filled with ^99mTc and ⁹⁰YCl₃ and scanned with SPECT/computed tomography [CT] and PET/CT, respectively. Gaussian blurring was applied to PET to match ^99mTc phantom scan image quality. After rigid registration between SPECT/CT and PET/CT, perturbations up to ±3 voxels were applied to determine the similarity metric (SM) sensitivity. ^99mTc-MAA SPECT/CT and ⁹⁰Y microsphere PET/CT image pairs/patients (n = 23) were processed analogously. SMs calculated included the Pearson correlation coefficient (ρ_r), Lin's concordance correlation coefficient (ρ_c), Spearman's rank correlation coefficient (ρ_s), the mean squared difference, and the Dice similarity coefficient (DSC). Patient-specific acceptance criteria were determined by evaluating the SMs of the blurred PET compared with itself misregistered.

Results

After transforming PET to SPECT resolution, high similarity was found in phantom, with ρ_c, ρ_r, ρ_s > 0.98 ± 0.01, a mean squared difference of (4.1 ± 0.3) × 10^-4 and DSC > 0.85 ± 0.01 for investigated thresholds (5%, 30%, and 50%). SMs for patients varied from poor to good. A small percentage (13%-30%) of patient scans were acceptable using phantom-based acceptance criteria. The percentage increased slightly (17%-35%) using patient-specific acceptance criteria. DSC for most patients were substantially lower (average 0.95 vs 0.61 for 5% threshold) than phantom values.

Conclusions

At best, 35% of patients had an SM within the acceptance criteria established to account for imaging-related effects impacting spatial concordance between ^99mTc-MAA SPECT and ⁹⁰Y PET. Additional clinical factors should be evaluated in the future. The procedure of accounting for image-related effects when assessing spatial concordance can be applied to other theranostic pairs.

SUBMITTER: Mikell JK

PROVIDER: S-EPMC8011284 | biostudies-literature |

REPOSITORIES: biostudies-literature

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