Ontology highlight
ABSTRACT:
SUBMITTER: Widjaja-Adhi MAK
PROVIDER: S-EPMC7722226 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Widjaja-Adhi Made Airanthi K MAK Silvaroli Josie A JA Chelstowska Sylwia S Trischman Thomas T Bederman Ilya I Sayegh Rony R Golczak Marcin M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20200826 10
Lipids secreted by the meibomian glands (MGs) of the eyelids are essential to the protection of the eye's surface. An altered meibum composition represents the primary cause of evaporative dry eye disease (DED). Despite the critical importance of the meibum, its biosynthetic pathways and the roles of individual lipid components remain understudied. Here, we report that the genetic deletion of Acyl-CoA:wax alcohol acyltransferase 2 (AWAT2) causes the obstruction of MGs and symptoms of evaporative ...[more]