Antibiotic use and risk of colorectal cancer: a systematic review and dose-response meta-analysis.

ABSTRACT:

Background

It is understudied whether the posed association of oral antibiotics with colorectal cancer (CRC) varies between antibiotic spectrums, colorectal continuum, and if a non-linear dose-dependent relationship is present.

Design

Three electronic databases and a trial platform were searched for all relevant studies, from inception until February 2020, without restrictions. Random-effects meta-analyses provided pooled effect-sizes (ES) with 95% confidence intervals (CI). Dose-response analyses modelling the relationship between number of days exposed to antibiotics and CRC risk were extended to non-linear multivariable random-effects models.

Results

Of 6483 identified publications ten were eligible, including 4.1 million individuals and over 73,550 CRC cases. The

SUBMITTER: Simin J 

PROVIDER: S-EPMC7722751 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature