Dataset Information

Antibiotic use and risk of colorectal cancer: a systematic review and dose-response meta-analysis.

ABSTRACT:

Background

It is understudied whether the posed association of oral antibiotics with colorectal cancer (CRC) varies between antibiotic spectrums, colorectal continuum, and if a non-linear dose-dependent relationship is present.

Design

Three electronic databases and a trial platform were searched for all relevant studies, from inception until February 2020, without restrictions. Random-effects meta-analyses provided pooled effect-sizes (ES) with 95% confidence intervals (CI). Dose-response analyses modelling the relationship between number of days exposed to antibiotics and CRC risk were extended to non-linear multivariable random-effects models.

Results

Of 6483 identified publications ten were eligible, including 4.1 million individuals and over 73,550 CRC cases. The pooled CRC risk was increased among individuals who ever-used antibiotics (ES = 1.17, 95%CI 1.05-1.30), particularly for broad-spectrum antibiotics (ES = 1.70, 95%CI 1.26-2.30), but not for narrow-spectrum antibiotic (ES = 1.11, 95% 0.93-1.32). The dose-response analysis did not provide strong evidence of any particular dose-response association, and the risk patterns were rather similar for colon and rectal cancer.

Discussion

The antibiotic use associated CRC risk seemingly differs between broad- and narrow-spectrum antibiotics, and possibly within the colorectal continuum. It remains unclear whether this association is causal, requiring more mechanistic studies and further clarification of drug-microbiome interactions.

SUBMITTER: Simin J

PROVIDER: S-EPMC7722751 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Antibiotic use and risk of colorectal cancer: a systematic review and dose-response meta-analysis.

Simin Johanna J Fornes Romina R Liu Qing Q Olsen Renate Slind RS Callens Steven S Engstrand Lars L Brusselaers Nele N

British journal of cancer 20200924 12

<h4>Background</h4>It is understudied whether the posed association of oral antibiotics with colorectal cancer (CRC) varies between antibiotic spectrums, colorectal continuum, and if a non-linear dose-dependent relationship is present.<h4>Design</h4>Three electronic databases and a trial platform were searched for all relevant studies, from inception until February 2020, without restrictions. Random-effects meta-analyses provided pooled effect-sizes (ES) with 95% confidence intervals (CI). Dose- ...[more]

PMID: 32968205

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Dataset Information

Antibiotic use and risk of colorectal cancer: a systematic review and dose-response meta-analysis.

Background

Design

Results

Discussion

Publications

Antibiotic use and risk of colorectal cancer: a systematic review and dose-response meta-analysis.

Similar Datasets

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