Ontology highlight
ABSTRACT:
SUBMITTER: Xiao T
PROVIDER: S-EPMC7723321 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Xiao Tianshu T Frey Gary G Fu Qingshan Q Lavine Christy L CL Scott David A DA Seaman Michael S MS Chou James J JJ Chen Bing B
Nature chemical biology 20200309 5
Combination antiretroviral therapy has transformed HIV-1 infection, once a fatal illness, into a manageable chronic condition. Drug resistance, severe side effects and treatment noncompliance bring challenges to combination antiretroviral therapy implementation in clinical settings and indicate the need for additional molecular targets. Here, we have identified several small-molecule fusion inhibitors, guided by a neutralizing antibody, against an extensively studied vaccine target-the membrane ...[more]