Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka T
PROVIDER: S-EPMC7723412 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
eLife 20201119
Older age is a strong shared risk factor for many chronic diseases, and there is increasing interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins was conducted in 997 individuals between 21 and 102 years of age. We identified 651 proteins associated with age (506 over-represented, 145 underrepresented with age). Mediation analysis suggested a role for partial <i>cis</i>-epigenetic control of protein expression with age. Of the age-associated proteins, 33.5% ...[more]