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Functional mechanism and clinical implications of MicroRNA-423 in human cancers.

ABSTRACT: MicroRNAs play a vital role in the regulatory mechanisms of tumorigenesis. Current research indicates that microRNA-423 (miR-423) is abnormally expressed in various human tumors and participates in multiple signaling pathways of cancer progression. In most studies, miR-423 was confirmed as oncomiR, while a few contradictory reports considered miR-423 as an anticancer miRNA. The paradoxical role in cancer may hinder the application of miR-423 as a diagnostic and therapeutic target. Simultaneously, the interaction mechanism between miR-423 and lncRNA also needs attention. In this review, we have summarized the dual role of aberrant miR-423 expression and its mechanisms in tumorigenesis, and the therapeutic potential of miR-423 in human tumors.

SUBMITTER: Ke R

PROVIDER: S-EPMC7724490 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Functional mechanism and clinical implications of MicroRNA-423 in human cancers.

Ke RuiSheng R Lv LiZhi L Zhang SiYu S Zhang FuXing F Jiang Yi Y

Cancer medicine 20201111 23

MicroRNAs play a vital role in the regulatory mechanisms of tumorigenesis. Current research indicates that microRNA-423 (miR-423) is abnormally expressed in various human tumors and participates in multiple signaling pathways of cancer progression. In most studies, miR-423 was confirmed as oncomiR, while a few contradictory reports considered miR-423 as an anticancer miRNA. The paradoxical role in cancer may hinder the application of miR-423 as a diagnostic and therapeutic target. Simultaneously ...[more]

PMID: 33174687

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