Dataset Information

Association between the occurrence of albuminuria and the risk of early dementia among older people upon health examination: a community-based cohort study in Taiwan.

ABSTRACT:

Objectives

This study aimed to investigate the associations between biochemical markers, renal function, health behaviours and dementia among older people.

Design

A retrospective cohort study.

Setting

Community-based health examination database from Taipei city.

Participants

In total, 35?434 older people were included from February 2005 to December 2012. To assess changes in renal function, we selected participants who attended health examinations at least twice and responded to the AD8 questionnaire in 2012. We excluded those with dementia at baseline.

Primary outcome measures

Early dementia was assessed using the AD8 questionnaire in 2012. Explanatory variables included demographic factors, health behaviours, biochemical markers and renal function. We used a Cox proportional hazard model to estimate the HR for early dementia onset.

Results

Individuals with mild albuminuria (HR 1.228; 95% CI 1.066 to 1.414), lower eGFR (HR 1.549; 95%?CI 1.319 to 1.820) and higher age (HR 1.022; 95%?CI 1.015 to 1.028) were associated with a high risk of early dementia. Older people with no alcohol intake (HR 0.872; 95%?CI 0.794 to 0.958), and higher education levels (HR 0.647; 95%?CI 0.589 to 0.710) were at a low risk of early dementia.

Conclusions

Elevated mild albuminuria and low eGFR were associated with a high risk of early dementia in this community-based cohort. Routine health examinations for older people can help screen out the high-risk population, and clinical management might reduce or delay the risk of early dementia.

SUBMITTER: Tseng TJ

PROVIDER: S-EPMC7725074 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between the occurrence of albuminuria and the risk of early dementia among older people upon health examination: a community-based cohort study in Taiwan.

Tseng Tzu-Jung TJ Yen Yun-Ting YT Yang Yuan-Han YH Chen Yen-Hsu YH Chan Ta-Chien TC

BMJ open 20201208 12

<h4>Objectives</h4>This study aimed to investigate the associations between biochemical markers, renal function, health behaviours and dementia among older people.<h4>Design</h4>A retrospective cohort study.<h4>Setting</h4>Community-based health examination database from Taipei city.<h4>Participants</h4>In total, 35 434 older people were included from February 2005 to December 2012. To assess changes in renal function, we selected participants who attended health examinations at least twice and ...[more]

PMID: 33293399

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Dataset Information

Association between the occurrence of albuminuria and the risk of early dementia among older people upon health examination: a community-based cohort study in Taiwan.

Objectives

Design

Setting

Participants

Primary outcome measures

Results

Conclusions

Publications

Association between the occurrence of albuminuria and the risk of early dementia among older people upon health examination: a community-based cohort study in Taiwan.

Similar Datasets

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