Effective SNP ranking improves the performance of eQTL mapping.
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ABSTRACT:
SUBMITTER: Jeng XJ
PROVIDER: S-EPMC7725394 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Effective SNP ranking improves the performance of eQTL mapping.
Jeng X Jessie XJ Rhyne Jacob J Zhang Teng T Tzeng Jung-Ying JY
Genetic epidemiology 20200326 6
Genome-wide expression quantitative trait loci (eQTLs) mapping explores the relationship between gene expression and DNA variants, such as single-nucleotide polymorphism (SNPs), to understand genetic basis of human diseases. Due to the large number of genes and SNPs that need to be assessed, current methods for eQTL mapping often suffer from low detection power, especially for identifying trans-eQTLs. In this paper, we propose the idea of performing SNP ranking based on the higher criticism stat ...[more]
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