Ontology highlight
ABSTRACT:
SUBMITTER: Walter JC
PROVIDER: S-EPMC7725951 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Walter Jean-Charles JC Rech Jérôme J Walliser Nils-Ole NO Dorignac Jérôme J Geniet Frédéric F Palmeri John J Parmeggiani Andrea A Bouet Jean-Yves JY
iScience 20201126 12
Bacterial ParB partitioning proteins involved in chromosomes and low-copy-number plasmid segregation are cytosine triphosphate (CTP)-dependent molecular switches. CTP-binding converts ParB dimers to DNA clamps, allowing unidimensional diffusion along the DNA. This sliding property has been proposed to explain the ParB spreading over large distances from <i>parS</i> centromere sites where ParB is specifically loaded. We modeled such a "clamping and sliding" mechanism as a typical reaction-diffusi ...[more]