Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC7726335 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Wang Lei L Chennupati Ramesh R Jin Young-June YJ Li Rui R Wang ShengPeng S Günther Stefan S Offermanns Stefan S
iScience 20201126 12
Vascular smooth muscle cells (VSMCs) represent the prevailing cell type of arterial vessels and are essential for blood vessel structure and homeostasis. They have substantial potential for phenotypic plasticity when exposed to various stimuli in their local microenvironment. How VSMCs maintain their differentiated contractile phenotype is still poorly understood. Here we demonstrate that the Hippo pathway effectors YAP and TAZ play a critical role in maintaining the differentiated contractile p ...[more]