Ontology highlight
ABSTRACT:
SUBMITTER: Caspi T
PROVIDER: S-EPMC7727001 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Caspi Talia T Straw Sam S Cheng Chew C Garnham Jack O JO Scragg Jason L JL Smith Jessica J Koshy Aaron O AO Levelt Eylem E Sukumar Piruthivi P Gierula John J Beech David J DJ Kearney Mark T MT Cubbon Richard M RM Wheatcroft Stephen B SB Witte Klaus K KK Roberts Lee D LD Bowen T Scott TS
Journal of the American Heart Association 20200905 18
Background People with chronic heart failure (CHF) experience severe skeletal muscle dysfunction, characterized by mitochondrial abnormalities, which exacerbates the primary symptom of exercise intolerance. However, the molecular triggers and characteristics underlying mitochondrial abnormalities caused by CHF remain poorly understood. Methods and Results We recruited 28 patients with CHF caused by reduced ejection fraction and 9 controls. We simultaneously biopsied skeletal muscle from the pect ...[more]