Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish.
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ABSTRACT:
SUBMITTER: Volkers M
PROVIDER: S-EPMC3283868 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Publications
Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish.
Völkers Mirko M Dolatabadi Nima N Gude Natalie N Most Patrick P Sussman Mark A MA Hassel David D
Journal of cell science 20120101 Pt 2
Mutations in the store-operated Ca²⁺ entry pore protein ORAI1 have been reported to cause myopathies in human patients but the mechanism involved is not known. Cardiomyocytes express ORAI1 but its role in heart function is also unknown. Using reverse genetics in zebrafish, we demonstrated that inactivation of the highly conserved zebrafish orthologue of ORAI1 resulted in severe heart failure, reduced ventricular systolic function, bradycardia and skeletal muscle weakness. Electron microscopy of ...[more]
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