Dataset Information

Comparative efficacy and safety of radiotherapy/cetuximab versus radiotherapy/chemotherapy for locally advanced head and neck squamous cell carcinoma patients: a systematic review of published, primarily non-randomized, data.

ABSTRACT:

Background

Cetuximab (CTX) has been approved to be administered concurrently with radiotherapy (RT) to treat locally advanced head and neck squamous cell carcinoma (HNSCC). The aim of this study was to assess the efficacy and safety of concurrent CTX with RT (ExRT).

Method

The PubMed, Cochrane Library, EMBASE databases were systematically searched to find relevant articles. The combined hazard ratio (HR), risk ratio (RR) and 95% confidence interval were calculated to assess the efficacy and safety of ExRT in contrast to concurrent platinum-based chemotherapy with RT (ChRT).

Results

In total, 32 articles with 4556 patients were included. The pooled HRs indicated that ExRT achieved an unfavorable overall survival (HR: 1.86, p?p?=?0.002), locoregional control (HR: 1.94, p?p?=?0.003) compared with ChRT for locally advanced HNSCC patients. In human papillomavirus-positive patient subgroups, ExRT showed inferior disease-specific survival (HR: 2.55, p?=?0.009) and locoregional control (HR: 2.27, p?p?p?p?=?0.04) compared with non-CTX groups (ChRT and RT), and was associated with lower incidence of anemia (RR: 0.35, p?=?0.009), leukocytopenia (RR: 0.17, p?p?p?p?=?0.007).

Conclusion

ChRT should remain the standard treatment for locally advanced HNSCC patients. ExRT was recognized as an effective alternative treatment for locally advanced HNSCC patients who experienced unbearable toxicities caused by non-CTX treatments.

SUBMITTER: Mei M

PROVIDER: S-EPMC7727048 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Comparative efficacy and safety of radiotherapy/cetuximab <i>versus</i> radiotherapy/chemotherapy for locally advanced head and neck squamous cell carcinoma patients: a systematic review of published, primarily non-randomized, data.

Mei Mei M Chen Yu-Huan YH Meng Tian T Qu Ling-Han LH Zhang Zhi-Yong ZY Zhang Xiao X

Therapeutic advances in medical oncology 20201208

<h4>Background</h4>Cetuximab (CTX) has been approved to be administered concurrently with radiotherapy (RT) to treat locally advanced head and neck squamous cell carcinoma (HNSCC). The aim of this study was to assess the efficacy and safety of concurrent CTX with RT (ExRT).<h4>Method</h4>The <i>PubMed, Cochrane Library, EMBASE</i> databases were systematically searched to find relevant articles. The combined hazard ratio (HR), risk ratio (RR) and 95% confidence interval were calculated to assess ...[more]

PMID: 33343720

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