Ontology highlight
ABSTRACT:
SUBMITTER: Heras G
PROVIDER: S-EPMC7727263 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Heras Gabriel G Namuduri Arvind Venkat AV Traini Leonardo L Shevchenko Ganna G Falk Alexander A Bergström Lind Sara S Jia Mi M Tian Geng G Gastaldello Stefano S
Journal of molecular cell biology 20190501 5
The muscle RING-finger protein-1 (MuRF1) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRF1 gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRF1 gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We ha ...[more]